Orthomolecular therapy

THE TALE OF THE CHOLESTEROL

Subjects on this page (quick menu)
Properties of cholesterol
The consequences of using medicine to reduce the cholesterol level:
- Coenzym Q10 deficiency
- The LDL-cholesterol
- LDL-cholesterol and the Trans fatty acids
- Shortage of Squaleen
- Shortage of Cholesterol
- Shortage of Selenoproteïns
- Other side effects
Conclusion
What can we do to maintain the health of our heart and vessels?
Schedule of what to use to maintain our heart and vessels in good shape
Use the following substances

Literature

The last year’s cholesterol has been given a worse name. It used to be below 10 mmol/ltr but this figure is being adjusted all the time. Cholesterol is made in all body cells but mainly in the liver, bowel, suprarenal glands, reproductive organs and placenta. A small part is given by nutrition. We gather that cholesterol is a poison of which we can die from. This is a big misunderstanding. With a shortage of cholesterol we will become seriously ill or die from cancer or a heart disease. That is why cholesterol is indispensable for a good health. 
A too much of cholesterol is a sign of disease like fever with an infection and not the cause. By oppression of fever the pneumonia cannot be healed and one’s health will not improve by artificially adjusting the level of cholesterol by poison.
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Properties of cholesterol
Cholesterol is an important sterol in the human body and a part of the plasma and the intracellular membranes. It can be found in the myelin structures of the brain and the central nerve system and little amounts in the membranes of mitochondria.

The liver turns cholesterol into gall salts which are needed for the transmissions of fat and the vitamins which can be dissolved in fat (vitamin A, E, D and K).

Cholesterol is important for building up with the steroid hormones. These are hormones of the suprarenal glands and the reproductive organs. The hormones of the suprenal glands are the corticosteroids and mineralo-corticosteriods. The gender hormones are the hormones which are made by the ovaries, the testicles, and the placenta (and before the placenta). They are important for the pregnancy, at birth, breastfeeding, the balance of the minerals and the released energy with the metabolism of fat, sugars and proteins.

From cholesterol the egosterol is made which can be transformed into vitamin D2 under the influence of the ultraviolet light of the sun. Vitamin D2 is important to the calcium metabolism (1).

Cholesterol is made in the body from Acetyl CoA which again is made of sugar, fat, proteins and vitamins (especially B5) from nutrition. The Acetyl CoA is transformed step by step into mevalonaat. Mevalonaat again is turned into:
· Cholesterol
· Coenzym Q10
Selenoproteins, selenoproteine N, glutathionperoxidasis, deiodinases.
The Coenzyme Q10 is necessary for letting the core of the cells function. Without this substance our muscles and nerves are not able to function correctly. Especially the heart muscle needs a lot of Coenzyme Q10 for all his energy.

The medicines that reduce the cholesterol level are called Statins. They prevent the building up of mevalonaat. The reaction will be a descent of the cholesterol level, Coenzyme Q10 and Selenoproteins. The Selenoproteins are important for the development of Selenoprotein N and glutathionperoxidasis. Last mentioned substance protects the body by maintaining and developing muscles (2). With a shortage, pain will appear to the muscles of the skeleton, muscle weakness and fatigue. These Selenoproteins also help to prevent from cancer.
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The consequences of using medicine to reduce the cholesterol level

Coenzym Q10 deficiency: (11
our muscles get weaker. Not directly with the younger people but on the long term it will. By weakness of the muscles they will faster be painful with exertion. The weakness of the heart will cause short-of-breath and extreme fatigue (10).
According to Langsjoen 70% of the users of statins will develop a defect of the heart. Also in Canada the physicians have been warned for the use of Lipitor in connection with heart failure (3).

The nerves are also dependant on a sufficient supply of Coenzyme Q10. Our body will become more sensitive, but our nerve system is suffering too. The astronaut Graveline gives a description in his book “Lipitor, thief of our memory” how the use of Lipitor caused times of amnesia. 
The brain cells and nerve system need cholesterol for their walls. At a shortage in the brain cells psychological side effects like depression, sleep disorders and amnesia will appear. Whit a shortage of cholesterol in the nerve system we obtain a damage of the nerves (peripheral polyneuropathy) which is characterized by weakness, insensibility, pain and tingling feet. By decreasing the resistance (Coenzyme Q10 is also important to our resistance) it may cause inflammation of the nerve system (16, 17).

With elder people (70 years and older) a high cholesterol level is connected to a longer life, mainly because they got less often cancer of infectious diseases (18). If they use medicine to decrease the cholesterol level, they have more chance to develop muscle weakness of intellectually capacity. This is a threat to the quality of life and survival in general (29).
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The LDL-cholesterol:  
this substance is indispensable to our body because it transports the Coenzyme Q10 and beta carotene. So this substance is not dangerous at all to our body for then our body would not form this substance itself. If there is not enough LDL-cholesterol a shortage of anti-oxidants will occur and the growth of cancer cells will not be stopped anymore.
LDL-cholesterol is fore runner of pregnenolone, DHEA and progesterone. These are hormones which slow down the aging process and are important for our health. Together with cholesterol they act as anti-oxidant by removing the toxic substances from our body (19, 20). 
Too much of LDL-cholesterol (the so-called unhealthy type of cholesterol) points out a disorder and this can be controlled with nutrition and vitamins. The LDL-cholesterol has to be in balance with the HDL-cholesterol and the regular cholesterol (21, 22).
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LDL-cholesterol and the Trans fatty acids:
The LDL-particles in the blood have a certain size. If they are too small there is more risk for diseases of the vessels. If they are too small there is more risk for diseases of the vessels. The big LDL particles will not harm us. The cause of the small LDL particles is eating Trans fatty acids which are retained artificially by hydrogenation the unsaturated fatty acids into hydrogenated saturated fatty acids.
With this hardening process hydrogen is led through oil with a decreased temperature. These fats are in deep frying fat, fast meals, biscuits, pastry, margarine and much more industrial fat. These artificial formed Trans fatty acids are harmful to us while full cream butter contains the good Trans fatty acids for us (23, 24). These unnatural Trans fatty acids also have the property to raise the LDL-cholesterol and to lower the HDL cholesterol (25, 26).
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Shortage of Squaleen:  
Squaleen is the forerunner of cholesterol but is also used in our body to make vitamin A, E, D and K. It is important to take extra vitamin A and D, especially in the winter for our resistance towards infections. Vitamin D and K are important to build up the bones so helps to prevent osteoporosis. Vitamin E is needed by many processes in our body as a free catcher of radicals.
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Shortage of Cholesterol: 
From cholesterol the genderhormons, gall salt and vitamin D are transformed and is it is part of the cell wall. Together with a shortage of Coenzyme Q10 it causes rhabdomydyse: the tendency to dissolve and weaken the muscles including your heart muscle. This rhabdomyolisis might cause damage to the kidneys and by the release of toxic muscle components it even can bring about a kidney failure (15). 
A descent of the gender hormones usually will not affect your love life in a positive manner (1, 4, 12).
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Shortage of selenoproteins:  
Glutathionperoxidase, selenoprotein N and deiodinase are transformed from selenoproteins.a shortage causes more chance to develop cancer. A selenoprotein N shortage gives muscular pain, muscle weakness and fatigue. So Coenzyme Q10 is not the only remedy that gives certain symptoms at a shortage (5, 6).
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Other side effects:  
The next side effects might occur by taking medicine to lower the cholesterol level: pneumonia, liver intoxication, fatal colitis ulcerosa, pancreatitis, tendinitis, muddy sight, headache, eczema, nausea and more gastro-intestinal disorders (28), aberration with the unborn child (30).
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Conclusion:

  1. Cholesterol is an important substance to the body. If the cholesterol level is too high, it means a shortage of vitamin B3 of B6 but this is not dangerous to the body. Statines are much more dangerous (7).
  2. The level of cholesterol has got nothing to do with artherosclerosis, diseases of the heart, brain haemorrhages of brain infarct (7).
  3. Decreasing your cholesterol level can make your life shorter and more miserable (7,4).
  4. Comparising investigations of statins and placebo did not show any improvement of heart and vessel diseases from the statin group  (8).
  5. Medicine to lower cholesterol make the immune system weak.
  6. Medicine to lower cholesterol increases the blood pressure, especially the diastolic.
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What can we do to maintain the health of our heart and vessels?

If you are still afraid and not convinced about the innocence of cholesterol, you should use vitamin B3 (niacin) (13, 14), vitamin B6 and taurine if you have a high level. The niacin causes hot flushes for half an hour. Take it after a hot meal. There is also a supplement which works more slowly and gives no flushes. If you have liver disorders, start with not more than 35 mgr a day or have you vitamin B3 level measured first. Vitamin B6 can always be taken in.
Using Coenzyme Q10 on a daily base, strengthens your heart and muscles and increases you life chance with 75% (27).
To avoid oxidized cholesterol (oxysterols) (these are not very healthy) you should not eat animal protein, like meat and milk. Use a lot of vitamin C, beta-carotene and Coenzyme Q10 (31).

It is very important to have the level of homocystein measured in your blood, combined with vitamin B 12, folic acid and magnesium. If the homocystein level is to high (more than 7 micromol/ltr) it is damaging and shows a deficiency of vitamin B12, folic acid, magnesium and betaine HCL. Do not drink milk for it slows down the absorption of the substances needed.
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Schedule of what to use to maintain our heart and vessels in good shape:

This schedule has been made from advices from specialists in heart and vessel diseases (32, 33, 34, 35).

  1. Eat a lot of vegetables and fruit. Favorite are the ones from your own garden and not from green houses. Because too much fertilizer is been used, vegetables only contain half of the vitamins and minerals than ten years ago (1986-1996) (36). Vegetables and fruit contain vitamin A and C, carotenoids, tannin, flavonoid and fyto-oestrogens. They all decreases the cholesterol level. The fibers take care of a better blood pressure when a good respiration (abdominal breathing) increases the transmission (37).
  2. Grain products decrease the chance of an ischemic stroke. Take them if you are not allergic to them (38).
  3. Obesitas increases the chance of strokes, especially if it is accompanied with diabetes and/or high blood pressure. Check the cause of your obesitas, a deficiency of minerals, vitamins or insulin resistance can be present.
  4. Chronic infections and bad teeth cause a high sedimentation and more chance of obtaining fatty plaques of your vessels (39). Brush your teeth well and have the mercury inlays replaced.
  5. Having a life sitting down and smoking a lot, increases your chances of a stroke. Do your daily exercises and move every hour if you have a sitting life (40, 41). Smoking and drinking coffee causes short term vessel dilation and then long term constrictions. That is how vessels get damaged where fat get stuck, what will result in a vessel constriction.
  6. Have your blood group checked out and hang onto the blood group diet. Do not drink milk because it contains a lot of cholesterol and salt.
  7. Use the following substances:
  • Coenzym Q 10 1-2 a day 100 mgr
  • To decrease the level of homocysteïne to 5 – 7 micromol/ltr take the next substances ( possibly after determination of blood samples):
    a. vitamin B 12 2000mcg/a week
    b. folic acid 2 mgr/a day
    c. pyridoxaal-5-fosfaat 1 x 50 mgr/a day
    d. betaïne HCL 3 x 1 tablet during the meals
    e. magnesiumorotaat 1 x 500 mgr/a day 
  • Niacine 3 x 100 mgr/a day after meals because of the hot flushes which might appear. There is also a supplement which works more slowly and gives no flushes. Have your liver functions tested because if you have disorders, niacin (=vitamin B3) must be measured out low. 
  • Vitamin C 3 x 1000-2000 mgr/a day 
  • Vitamin E complex 2 -3 x 400 mgr/a day 
  • EPA/DHA=omega 3 2 x 500-1000 mgr/a day and is a good source to alfalinoleen acid like line seed and fat fish. 
  • Garlic 25-100 mgr/kilo bodyweight. 
  • Proline 3000 mgr/a day 
  • l-lysine 6000 mgr/a day 
  • Vitamin D 1000 IE/a day. And a shortage might disturb the calcium metabolism and causes heart failure (42).

The reason that doctors and specialists give descriptions for medicine to decrease the cholesterol is the marketing of the pharmaceutical industry which gives false information and will not mention the figures of investigation which do not fit their strategy. Medicine which decreases the cholesterol level can kill you.
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Literature:

1. Textbook of Biochemistry van Thomas M. Devlin.
2. Moosmann B, Behl C, Lancet 2004; 363(9412):892-4
3. Canadese editie New England Journal of Medicine 15 jan. 2004.
4. cholesterolverlaging, statines, hartfalen, kanker, geheugenverlies.Ortho 22e jaargang, nummer 2, 2004.
5. statines remmen Selenoproteïnen. Ortho 22e jaargang, nummer 2,2004.
6. Lancet 2004;363(9412): 892-4
7. de cholesterolmythe: Ortho 21e jaargang nummer 2, 2003, pag. 56-62.
8. het Mierlo project van Dr. G.E.Schuitemaker.
9. cardiovasc Med. 2001;2(5):205-207
10. statins and chronic heart failure. J.Am Coll Cardiol 2002 May15;39(10): 1567-73.
11. Langsjoen PH, Langsjoen AM. Biofactors, 2003;18(1-4):101-11.
12. Libido-afname en gebruik van statines. Br.J.Clin. Pharmacol. 2004 Sep; 58(3);326-8.
13. Effect of niacin and atorvastin on lipoprotein subclasses in patients with atherogenic dyslipidemia. Mc Kenney JM et al. Am. J Cardiol 2001 AUG 1:88(3);270-4.
14. Faché, W OM Orthomoleculaire Geneeskunde; deel 8, Hart- en bloedvaatziekten VIOW, 2000.
15. Ann. Pharmacother. 2002;36: 288-95.
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17. Neurology, 2002; 14:1333-7
18. Lancet, 1997; 350: 1119-23.
19. Earthletter, 1993; Spring
20. Free Rad. Biol and Med, 1991; 11:47-61.
21. N Engl J. Med. 1999;341:410-8
22. Proc Nutr Soc. 2003; 62:135-42
23. Can. J. Cardiol. 2001; 17:859-65.
24. Am. J. Public Health 1994; 84:722-4
25. Am. J. Clin Nutr 2003; 78: 370-5
26. Ortho. 22e jaargang 2004 no 1 pag. 34-38
27. Am. J. Cardio, 1990;65: 521-3
28. BMJ. 2000; 320: 1583-4
29. Lancet, 1989; i: 868-70
30. N. Engl. J. Med. 2004 8; 350(15): 1579-82.
31. J.Orth. Medicine, 1991; 6:83-98.
32. Ortho 22e jaargang no. 3. 2004
33. Medisch Dossier jaargang 3 nr.2 en 4. 2001
34. Medisch Dossier jaargang 6 nr. 2. Februari 2004.
35. L. Pruimboom seminar. BV Uitgeverij Van Nature 2004.
36. Orthofyto jaargang 10, juli-aug. 2004 pag.277
37. Int. J. Epidemiol. 1997;26: 1-13
38. JAMA. 2000; 284:1534-40
39. Arch Intern Med. 2000;160:2749-55
40. Am. J. Epidemiol. 1996; 143:860-9.
41. Stroke, 1998; 29:2049-54.
42. J. Am Coll Cardiol 2003;41(1): 105-12.
43. De Cholesterolleugen; Prof.Dr. Walter Hartenbach. . Uitgeverij Ankh-Hermes bv-Deventer en The Great Cholesterol Con van Anthony Colpo. ISBN 978-1-4116-9475-0.
44. Lancet 2007: 369: 268-269.
45. Malignant Medical Myths: Joel M. Kauffmann, Ph.D. Myth 3:78-105 ISBN 0-7414-2909-8.
 

J.Beunk
Homeopatisch en Orthomoleculair arts
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